i'm fine good work clomiphene citrate challenge test ovarian reserve ehden Expression wrinkles, says Dr. Glogau, can be improved by various means, including wrinkle creams, skin resurfacing, plastic surgery and injections of Botox, which, by weakening the muscles underlying the skin, reduces their contractions. Sleep wrinkles, however, cannot be improved with Botox, he explains, because contractions do not cause them.